Oxidized LDL Is Strictly Limited to Hyperthyroidism Irrespective of Fat Feeding in Female Sprague Dawley Rats

International Journal of Molecular Sciences

Sieglinde Zelzer⁴  Harald Mangge⁴  Sabine Pailer⁴  Herwig Ainoedhofer⁴  Petra Kieslinger⁴  Tatjana Stojakovic⁴  Hubert Scharnagl⁴  Florian Prüller⁴  Daniel Weghuber⁵  Christian Datz⁶  Johannes Haybaeck²  Barbara Obermayer-Pietsch¹  Christian Trummer¹  Johanna Gostner³  Hans-Jürgen Gruber⁴ 

[1] Division of Endocrinology and Metabolism, Medical University Graz, 8036 Graz, Austria; E-Mails:;Department of Pathology, Medical University of Graz, 8036 Graz, Austria; E-Mail:;Medical Biochemistry, Center of Chemistry and Biomedicine, Medical University of Innsbruck, 6020 Innsbruck, Austria; E-Mail:;Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, 8036 Graz, Austria; E-Mails:;Department of Pediatrics, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria; E-Mail:;Obesity Research Unit, Paracelsus Medical University and Salzburger Landeskliniken, 5020 Salzburg, Austria; E-Mail:

关键词: hyperthyroidism;    oxidized LDL;    hypothyroidism;    fat feeding;    metabolic dysfunction;    Sprague Dawley rats;   

DOI  :  10.3390/ijms160511689

来源: mdpi

【 摘 要 】

Metabolic dysfunctions might play a crucial role in the pathophysiology of thyroid dysfunctions. This study aimed to investigate the impact of a controlled diet (normal versus high fat feeding) on hypothyroid and hyperthyroid Sprague Dawley rats. Female Sprague Dawley rats (n = 66) were grouped into normal diet (n = 30) and high-fat diet (n = 36) groups and subdivided into controls, hypothyroid and hyperthyroid groups, induced through propylthiouracil or triiodothyronine (T3) treatment, respectively. After 12 weeks of treatment metabolic parameters, such as oxidized LDL (oxLDL), malondialdehyde (MDA), 4-hydroxynonenal (HNE), the lipid profile, body weight and food intake parameters were analyzed. Successfully induced thyroid dysfunctions were shown by T3 levels, both under normal and high fat diet. Thyroid dysfunctions were accompanied by changes in calorie intake and body weight as well as in the lipid profile. In detail, hypothyroid rats showed significantly decreased oxLDL levels, whereas hyperthyroid rats showed significantly increased oxLDL levels. These effects were seen under high fat diet and were less pronounced with normal feeding. Taken together, we showed for the first time in female SD rats that only hyper-, but not hypothyroidism, is associated with high atherogenic oxidized LDL irrespective of normal or high-fat diet in Sprague Dawley rats.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.