Hypothyroidism Exacerbates Thrombophilia in Female Rats Fed with a High Fat Diet

International Journal of Molecular Sciences

Harald Mangge³  Florian Prüller³  Sieglinde Zelzer³  Herwig Ain཭hofer³  Sabine Pailer³  Petra Kieslinger³  Johannes Haybaeck⁴  Barbara Obermayer-Pietsch¹  Gerhard Cvirn²  Hans-Jürgen Gruber³ 

[1] Division of Endocrinology and Metabolism, Medical University Graz, 8036 Graz, Austria; E-Mail:;Physiological Chemistry, Medical University of Graz, 8036 Graz, Austria; E-Mail:;Clinical Institute for Medical and Chemical Laboratory Diagnostics, Medical University Graz, 8036 Graz, Austria; E-Mails:;Department of Pathology, Medical University of Graz, 8036 Graz, Austria; E-Mail:

关键词: endogenous thrombin potential (ETP);    hyperthyroidism;    hypothyroidism;    fat feeding;    Sprague Dawley rats;   

DOI  :  10.3390/ijms160715776

来源: mdpi

【 摘 要 】

Clotting abnormalities are discussed both in the context with thyroid dysfunctions and obesity caused by a high fat diet. This study aimed to investigate the impact of hypo-, or hyperthyroidism on the endogenous thrombin potential (ETP), a master indicator of clotting activation, on Sprague Dawley rats fed a normal or high fat diet. Female Sprague Dawley rats (n = 66) were grouped into normal diet (ND; n = 30) and high-fat diet (HFD; n = 36) groups and subdivided into controls, hypothyroid and hyperthyroid groups, induced through propylthiouracil or triiodothyronine (T3) treatment, respectively. After 12 weeks of treatment ETP, body weight and food intake were analyzed. Successfully induced thyroid dysfunction was shown by T3 levels, both under normal and high fat diet. Thyroid dysfunction was accompanied by changes in calorie intake and body weight. In detail, compared to euthyroid controls, hypothyroid rats showed significantly increased—and hyperthyroid animals significantly decreased—ETP levels. High fat diet potentiated these effects in both directions. In summary, we are the first to show that hypothyroidism and high fat diet potentiate the thrombotic capacity of the clotting system in Sprague Dawley rats. This effect may be relevant for cardiovascular disease where thyroid function is poorly understood as a pathological contributor in the context of clotting activity and obesogenic nutrition.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.