Synthesis, Structural Characterization and Biological Activity of Novel Cyclohexane-1,3-dione Ligands and Their Metal Complexes

Molecules

Nevin Turan¹  Hanifi Körkoca³  Ragıp Adigüzel²  Naki Colak⁴  Kenan Buldurun¹ 

[1] Department of Chemistry, Faculty of Arts and Sciences, Muş Alparslan University, 49250 Muş, Turkey; E-Mail:;Department of Chemical Engineering, Faculty of Engineering, Tunceli University, 62000 Tunceli, Turkey; E-Mail:;Nursing Department, School of Health, Muş Alparslan University, 49250 Muş, Turkey; E-Mail:;Department of Chemistry, Faculty of Arts and Sciences, Hitit University, 19100 Çorum, Turkey; E-Mail:

关键词: cyclohexane-1;    3-dione;    antibacterial activity;    metal complexes;    mass spectra;    spectroscopic characterization;   

DOI  :  10.3390/molecules20059309

来源: mdpi

【 摘 要 】

Some new Zn(II) and Cu(II) complexes [Cu(L¹)(OAc)₂]∙H₂O, [Cu(L¹)(NO₃)H₂O]∙NO₃∙3.5H₂O, [Zn(L¹)(NO₃)₂]∙4.5H₂O, [Zn(L¹)(OAc)₂(H₂O)₂]∙3H₂O, [Cu₂(L²)(OAc)₄]∙2H₂O∙2DMF, [Cu(L²)₂]∙2NO₃∙1.5DMF∙H₂O, [Zn(L²)₂(NO₃)₂]∙DMF and [Zn₂(L²)(OAc)₄(H₂O)₄]∙5H₂O; L¹ = 2-[2-(2-methoxyphenyl)hydrazono]cyclohexane-1,3-dione and L² = 2-[2-(3-nitrophenyl)hydrazono]cyclohexane-1,3-dione were synthesized and characterized by IR, ¹H-NMR,¹³C-NMR and ultraviolet (UV-Vis.) spectroscopy, elemental analysis, magnetic susceptibility, mass spectrometry and thermogravimetry-differential thermal analysis (TGA-DTA). The synthesized ligands and their complexes were tested for antibacterial activity against Escherichia coli ATCC 25922, Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 25923, and Salmonella typhimurium CCM 583. Some of complexes showed medium-level antibacterial activity against the test bacteria compared with ampicillin.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.