Alternative and Efficient Extraction Methods for Marine-Derived Compounds

Marine Drugs

Clara Grosso¹  Patrໜia Valentão¹  Federico Ferreres²  Paula B. Andrade¹ 

[1] REQUIMTE/LAQV, Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, no. 228, Porto 4050-313, Portugal; E-Mails:;Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS (CSIC), P.O. Box 164, 30100 Campus University Espinardo, Murcia 30100, Spain; E-Mail:

关键词: marine compounds;    enzyme-assisted extraction;    ionic liquids;    microwave-assisted extraction;    pressurized solvent extraction;    pulsed electric field-assisted extraction;    supercritical fluid extraction;    ultrasound-assisted extraction;    switchable solvents;   

DOI  :  10.3390/md13053182

来源: mdpi

【 摘 要 】

Marine ecosystems cover more than 70% of the globe’s surface. These habitats are occupied by a great diversity of marine organisms that produce highly structural diverse metabolites as a defense mechanism. In the last decades, these metabolites have been extracted and isolated in order to test them in different bioassays and assess their potential to fight human diseases. Since traditional extraction techniques are both solvent- and time-consuming, this review emphasizes alternative extraction techniques, such as supercritical fluid extraction, pressurized solvent extraction, microwave-assisted extraction, ultrasound-assisted extraction, pulsed electric field-assisted extraction, enzyme-assisted extraction, and extraction with switchable solvents and ionic liquids, applied in the search for marine compounds. Only studies published in the 21st century are considered.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.