Dietary Inflammatory Index and Incidence of Cardiovascular Disease in the PREDIMED Study

Nutrients

Ana Garcia-Arellano³  Raul Ramallal⁵  Miguel Ruiz-Canela⁴  Jordi Salas-Salvadó⁴  Dolores Corella²  Nitin Shivappa¹  Helmut Schrr²  James R. Hrt¹  Emilio Ros²  Enrique Gómez-Garcia⁴  Ramon Estruch⁴  José Lapetra²  Fernando Arós⁴  Miquel Fiol²  Lluis Serra-Majem⁴  Xavier Pintó⁴  Nancy Babio⁴  José I. González²  Montse Fitó²  J. Alfredo Martínez⁴  Miguel A. Martínez-González⁴ 

[1] South Carolina Statewide Cancer Prevention and Control Program, University of South Carolina, Columbia, SC, 29208 USA; E-Mails:;Centro de Investigación Biomédica en Epidemiología y Salud Pública, Madrid 28029, Spain; E-Mails:;Department of Emergency, Complejo Hospitalario de Navarra, Servicio Navarro de Salud, Pamplona 31008, Spain; E-Mail:;The PREDIMED (Prevención con Dieta Mediterránea) Research Network (RD 06/0045), Instituto de Salud Carlos III, Madrid 28029, Spain; E-Mails:;Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, Pamplona 31008, Spain; E-Mail:

关键词: dietary inflammatory index;    cardiovascular disease;    PREDIMED;    inflammation;   

DOI  :  10.3390/nu7064124

来源: mdpi

【 摘 要 】

Previous studies have reported an association between a more pro-inflammatory diet profile and various chronic metabolic diseases. The Dietary Inflammatory Index (DII) was used to assess the inflammatory potential of nutrients and foods in the context of a dietary pattern. We prospectively examined the association between the DII and the incidence of cardiovascular disease (CVD: myocardial infarction, stroke or cardiovascular death) in the PREDIMED (Prevención con Dieta Mediterránea) study including 7216 high-risk participants. The DII was computed based on a validated 137-item food frequency questionnaire. Multivariate-adjusted hazard ratios (HR) and 95% confidence intervals of CVD risk were computed across  quartiles of the DII where the lowest (most anti-inflammatory) quartile is the referent. Risk increased across the quartiles (i.e., with increasing inflammatory potential): HR_quartile2 = 1.42 (95%CI = 0.97–2.09); HR_quartile3 = 1.85 (1.27–2.71); and HR_quartile4 =1.73 (1.15–2.60). When fit as continuous the multiple-adjusted hazard ratio for each additional standard deviation of the DII was 1.22 (1.06–1.40). Our results provide direct prospective evidence that a pro-inflammatory diet is associated with a higher risk of cardiovascular clinical events.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.