Impact of Intensive Lifestyle Treatment (Diet Plus Exercise) on Endothelial and Vascular Function, Arterial Stiffness and Blood Pressure in Stage 1 Hypertension: Results of the HINTreat Randomized Controlled Trial

Nutrients

MariaG. Grammatikopoulou¹  Pantelis Zebekakis²  Christos Tzimos³  Stella Douma⁴  Panagiota Anyfanti⁴  Eugenia Gkaliagkousi⁴  Anastasios Vamvakis⁴  Antonios Lazaridis⁴  Areti Triantafyllou⁴  Nikolaos Koletsos⁴  Barbara Nikolaidou⁴ 

[1] Department of Nutritional Sciences & Dietetics, Faculty of Health Sciences, International Hellenic University, Alexander Campus, Sindos, PO Box 141, GR57400 Thessaloniki, Greece;Division of Endocrinology and Metabolism and Diabetes Center, First Department of Internal Medicine, Medical School, AHEPA University Hospital, Aristotle University of Thessaloniki, GR54621 Thessaloniki, Greece;Northern Greece Statistics Directorate, Hellenic Statistical Authority, 218 Delfon Str, GR54646 Thessaloniki, Greece;Third Department of Internal Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, GR56403 Thessaloniki, Greece;

关键词: hypertension;    asymmetric dimethylarginine;    dietary inflammatory index;    endothelial dysfunction;    inflammation;    medical nutrition therapy;   

DOI  :  10.3390/nu12051326

来源: DOAJ

【 摘 要 】

Lifestyle modification is an important component of essential hypertension (EH) therapy. The aim of the Hypertension Intensive Nutrition Treatment (HINTreat) parallel, randomized controlled trial was to examine the effect of a 6-month intensive lifestyle treatment (ILT) (diet plus exercise with monthly visits) compared to the usual care. A total of 76 adults with stage 1 EH were randomized (38 in each group). Dietary analysis, anthropometry, physical activity, biochemical and urine profile, blood pressure (BP), asymmetric dimethylarginine (ADMA), central hemodynamics, β-stiffness index and carotid intima media-thickness were evaluated. The dietary inflammatory index (DII) was calculated for each participant from the intake of 29 nutrients/food components. At the end of the trial, participants in the ILT group reduced their 24h urinary Na excretion (p ≤ 0.001), daytime systolic BP (p ≤ 0.048) and mean carotid β-stiffness index (p ≤ 0.005) and ameliorated their lipidemic profile compared to the standard care. Univariate analysis for the total sample showed a strong association between DII and ADMA levels (β = 0.089, p ≤ 0.01). ILT is effective in improving the inflammatory components of the diet and selected cardiometabolic parameters, including arterial stiffness.

【 授权许可】

Unknown