Drimane Sesquiterpene-Conjugated Amino Acids from a Marine Isolate of the Fungus Talaromyces minioluteus (Penicillium Minioluteum)

Marine Drugs

Suthatip Ngokpol¹  Wittaya Suwakulsiri²  Sanya Sureram¹  Kriengsak Lirdprapamongkol¹  Thammarat Aree⁴  Suthep Wiyakrutta³  Chulabhorn Mahidol¹  Somsak Ruchirawat¹  Prasat Kittakoop¹ 

[1] Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand; E-Mails:;Chulabhorn Graduate Institute, Chemical Biology Program, Laksi, Bangkok 10210, Thailand; E-Mail:;Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand; E-Mail:;Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand; E-Mail:

关键词: marine fungi;    Talaromyces minioluteus;    Penicillium minioluteum;    sesquiterpene;    drimane;    caspase-3;    cytotoxic activity;    fungal metabolites;   

DOI  :  10.3390/md13063567

来源: mdpi

【 摘 要 】

Four new sesquiterpene lactones (3, 4, 6 and 7) and three known compounds, purpuride (1), berkedrimane B (2) and purpuride B (5), were isolated from the marine fungus, Talaromyces minioluteus (Penicillium minioluteum). New compounds were drimane sesquiterpenes conjugated with N-acetyl-l-valine, and their structures were elucidated by analysis of spectroscopic data, as well as by single crystal X-ray analysis. The isolated compounds could not inhibit the apoptosis-regulating enzyme, caspase-3, while three of the compounds (2, 3 and 7) exhibited weak cytotoxic activity.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.