Marine Drugs | |
Fucoidan Suppresses Hypoxia-Induced Lymphangiogenesis and Lymphatic Metastasis in Mouse Hepatocarcinoma | |
Hongming Teng1  Yazong Yang1  Hengyun Wei1  Zundong Liu1  Zhichao Liu1  Yanhong Ma1  Zixiang Gao1  Lin Hou2  Xiangyang Zou1  | |
[1] Department of Biotechnology,Dalian Medical University, Dalian 116044, China; E-Mails:;College of Life Sciences, Liaoning Normal University, Dalian 116081, China | |
关键词: fucoidan; lymphangiogenesis; hypoxia; HIF-1α; metastasis; | |
DOI : 10.3390/md13063514 | |
来源: mdpi | |
【 摘 要 】
Metastasis, the greatest clinical challenge associated with cancer, is closely connected to multiple biological processes, including invasion and adhesion. The hypoxic environment in tumors is an important factor that causes tumor metastasis by activating HIF-1α. Fucoidan, extracted from brown algae, is a sulfated polysaccharide and, as a novel marine biological material, has been used to treat various disorders in China,Korea, Japan and other countries. In the present study, we demonstrated that fucoidan derived from
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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