Comparison of Selective Laser Melted Titanium and Magnesium Implants Coated with PCL

International Journal of Molecular Sciences

Julia Matena⁴  Svea Petersen⁶  Matthias Gieseke¹  Michael Teske²  Martin Beyerbach⁷  Andreas Kampmann³  Hugo Murua Escobar⁴  Nils-Claudius Gellrich³  Heinz Haferkamp⁵  Ingo Nolte⁴ 

[1] Institute for Biomedical Engineering, Rostock University Medical Center, D-18119 Rostock, Germany; E-Mail:;Materials and Processes Department, Laser Zentrum Hannover e.V., D-30419 Hannover, Germany; E-Mail:;Clinic for Cranio-Maxillo-Facial Surgery, Hannover Medical School, D-30625 Hannover, Germany; E-Mails:;Small Animal Clinic, University of Veterinary Medicine Hannover, Foundation, D-30559 Hannover, Germany; E-Mails:;Institut fuer Werkstoffkunde, Leibniz Universitaet Hannover, D-30823 Hannover, Germany; E-Mail:;Faculty of Engineering and Computer Science, Osnabrueck University of Applied Sciences, D-49076 Osnabrueck, Germany; E-Mail:;Institute for Biometry, Epidemiology and Information Processing, University of Veterinary Medicine Hannover, Foundation, D-30559 Hannover, Germany; E-Mail:

关键词: titanium implant;    magnesium implant;    polycaprolactone;    poly-3-hydroxybutyrate;    live cell imaging;    osteoblast;   

DOI  :  10.3390/ijms160613287

来源: mdpi

【 摘 要 】

Degradable implant material for bone remodeling that corresponds to the physiological stability of bone has still not been developed. Promising degradable materials with good mechanical properties are magnesium and magnesium alloys. However, excessive gas production due to corrosion can lower the biocompatibility. In the present study we used the polymer coating polycaprolactone (PCL), intended to lower the corrosion rate of magnesium. Additionally, improvement of implant geometry can increase bone remodeling. Porous structures are known to support vessel ingrowth and thus increase osseointegration. With the selective laser melting (SLM) process, defined open porous structures can be created. Recently, highly reactive magnesium has also been processed by SLM. We performed studies with a flat magnesium layer and with porous magnesium implants coated with polymers. The SLM produced magnesium was compared with the titanium alloy TiAl6V4, as titanium is already established for the SLM-process. For testing the biocompatibility, we used primary murine osteoblasts. Results showed a reduced corrosion rate and good biocompatibility of the SLM produced magnesium with PCL coating.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.