A Halogen-Containing Stilbene Derivative from the Leaves of Cajanus cajan that Induces Osteogenic Differentiation of Human Mesenchymal Stem Cells

Molecules

Jia-Zhong Cai²  Rong Tang²  Gui-Fu Ye²  Sheng-Xiang Qiu¹  Nen-Ling Zhang¹  Ying-Jie Hu²  Xiao-Ling Shen² 

[1] Program for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China; E-Mails:;Laboratory of Chinese Herbal Drug Discovery, Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, China; E-Mails:

关键词: Cajanus cajan (L.) Millsp.;    stilbene;    halogen;    cajanstilbene H;    osteogenic diffrentiation;    human mesenchymal stem cells;   

DOI  :  10.3390/molecules200610839

来源: mdpi

【 摘 要 】

A new natural halogen-containing stilbene derivative was isolated from the leaves of Cajanus cajan (L.) Millsp. and identified as 3-O-(3-chloro-2-hydroxyl-propanyl)-longistylin A by comprehensive spectroscopic and chemical analysis, and named cajanstilbene H (1). It is the first halogen-containing stilbene derivative found from plants. In human mesenchymal stem cells (hMSC) from bone marrow, 1 did not promote cell proliferation, but distinctly enhanced osteogenic differentiation of hMSC in time- and dose-dependent manners. In six human cancer cell lines, 1 showed a moderate inhibitory effect on cell proliferation, with IC₅₀ values of 21.42–25.85 μmol·L⁻¹.

【 授权许可】

CC BY   
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