Genetics of Type 2 Diabetes and Clinical Utility

Genes

Rajkumar Dorajoo¹  Jianjun Liu¹  Bernhard O. Boehm¹ 

[1] Genome Institute of Singapore, Agency for Science, Technology and Research, 138672, Singapore; E-Mails:

关键词: type 2 diabetes;    genetics;    clinical utility;   

DOI  :  10.3390/genes6020372

来源: mdpi

【 摘 要 】

A large proportion of heritability of type 2 diabetes (T2D) has been attributed to inherent genetics. Recent genetic studies, especially genome-wide association studies (GWAS), have identified a multitude of variants associated with T2D. It is thus reasonable to question if these findings may be utilized in a clinical setting. Here we briefly review the identification of risk loci for T2D and discuss recent efforts and propose future work to utilize these loci in clinical setting—for the identification of individuals who are at particularly high risks of developing T2D and for the stratification of specific health-care approaches for those who would benefit most from such interventions.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.