A Multi-Target Approach toward the Development of Novel Candidates for Antidermatophytic Activity: Ultrastructural Evidence on α-Bisabolol-Treated Microsporum gypseum

Molecules

Carlo Romagnoli²  Anna Baldisserotto¹  Gemma Malisardi¹  Chiara B. Vicentini¹  Donatella Mares¹  Elisa Andreotti²  Silvia Vertuani¹  Stefano Manfredini¹ 

[1] Department of Life Sciences and Biotechnology, Master Course in Cosmetic Science and Technology, University of Ferrara, via Fossato di Mortara 17-19, 44121 Ferrara, Italy; E-Mails:;Department of Life Sciences, University of Modena and Reggio Emilia, viale Caduti in Guerra 127, 41121 Modena, Italy; E-Mails:

关键词: antifungal activity;    dermatophytes;    M. gypseum;    α-bisabolol;    TEM;    skin lightener;   

DOI  :  10.3390/molecules200711765

来源: mdpi

【 摘 要 】

Multi-target strategies are directed toward targets that are unrelated (or distantly related) and can create opportunities to address different pathologies. The antidermatophytic activities of nine natural skin lighteners: α-bisabolol, kojic acid, β-arbutin, azelaic acid, hydroquinone, nicotinamide, glycine, glutathione and ascorbyl tetraisopalmitate, were evaluated, in comparison with the known antifungal drug fluconazole, on nine dermatophytes responsible for the most common dermatomycoses: Microsporum gypseum, Microsporum canis, Trichophyton violaceum, Nannizzia cajetani, Trichophyton mentagrophytes, Epidermophyton floccosum, Arthroderma gypseum, Trichophyton rubrum and Trichophyton tonsurans. α-Bisabolol showed the best antifungal activity against all fungi and in particular; against M. gypseum. Further investigations were conducted on this fungus to evaluate the inhibition of spore germination and morphological changes induced by α-bisabolol by TEM.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.