Antifungal Activity Evaluation of the Constituents of Haliclona baeri and Haliclona cymaeformis, Collected from the Gulf of Thailand

Marine Drugs

Rawiwan Wattanadilok²  Pichan Sawangwong⁵  Cátia Rodrigues³  Honorina Cidade³  Madalena Pinto³  Eugenia Pinto¹  Artur Silva⁴ 

[1] Laboratório de Microbiologia, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha 164, 4050-047 Porto, Portugal;Bangsaen Institute of Marine Science (BIMS), Burapha University, Bangsaen, Chonburi 20131, Thailand;Laboratório de Química Orgânica, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha 164, 4050-047 Porto, Portugal;Departamento de Química, Universidade de Aveiro, 4810-1933 Aveiro, Portugal;Department of Aquatic Science, Faculty of Sciences, Burapha University, Bangsaen, Chonburi 20131, Thailand

关键词: Haliclona baeri;    Haliclona cymaeformis;    tetillapyrone;    nortetillapyrone;    antifungal activity;    dermatophytes;   

DOI  :  10.3390/md502040

来源: mdpi

【 摘 要 】

A new compound maleimide-5-oxime was isolated, together with 3,4-dihydroxybenzoic acid, tetillapyrone, from the ethyl acetate extract of the marine sponge Haliclona baeri while tetillapyrone, nortetillapyrone, p-hydroxybenzaldehyde and phenylacetic acid were isolated from the ethyl acetate extract of Haliclona cymaeformis, collected from the Gulf of Thailand. The structures of tetillapyrone and nortetillapyrone were re-examined using HMBC correlations. Maleimide-5-oxime, tetillapyrone and nortetillapyrone were found to be inactive against three human tumor cell lines (the estrogen-dependent ER(+) MCF-7, the estrogen-independent ER(−) MDA-MB-231 and NCI-H460. Maleimide-5-oxime, p-hydroxybenzaldehyde, phenylacetic acid, tetillapyrone and nortetillapyrone were evaluated for their growth inhibitory effect against seven yeasts and eight filamentous fungi. Only nortetillapyrone showed antifungal activity, with a preponderance on the dermatophytic filamentous fungi.

【 授权许可】

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