Comorbidities and Quality of Life among Breast Cancer Survivors: A Prospective Study

Journal of Personalized Medicine

Mei R. Fu³  Deborah Axelrod⁴  Amber A. Guth⁴  Charles M. Cleland³  Caitlin E. Ryan³  Kristen R. Weaver³  Jeanna M. Qiu³  Robin Kleinman²  Joan Scagliola²  Joseph J. Palamar¹  Gail D𠆞ramo Melkus³ 

[1] Department of Population Health, New York University, New York, NY 10016, USA; E-Mail:;NYU Clinical Cancer Center, New York, NY 10016, USA; E-Mails:;College of Nursing, New York University, New York, NY 10010, USA; E-Mails:;Department of Surgery, New York University School of Medicine, New York, NY 10016, USA; E-Mails:

关键词: comorbidity;    breast cancer;    quality of life;    chronic illness;   

DOI  :  10.3390/jpm5030229

来源: mdpi

【 摘 要 】

Many breast cancer survivors have coexistent chronic diseases or comorbidities at the time of their cancer diagnosis. The purpose of the study was to evaluate the association of comorbidities on breast cancer survivors’ quality of life. A prospective design was used to recruit 140 women before cancer surgery, 134 women completed the study. Comorbidities were assessed using self-report and verified by medical record review and the Charlson Comorbidity Index (CCI) before and 12-month after cancer surgery. Quality of life was evaluated using Short-Form Health Survey (SF-36 v2). Descriptive statistics, chi-square tests, t-tests, Fisher’s exact test, and correlations were performed for data analysis. A total of 28 comorbidities were identified. Among the 134 patients, 73.8% had at least one of the comorbidities, 54.7% had 2–4, and only 7.4% had 5–8. Comorbidities did not change at 12 months after surgery. Numbers of comorbidities by patients’ self-report and weighted categorization of comorbidities by CCI had a similar negative correlation with overall quality of life scores as well as domains of general health, physical functioning, bodily pain, and vitality. Comorbidities, specifically hypertension, arthritis, and diabetes, were associated with poorer quality of life in multiple domains among breast cancer survivors. Future research should consider the combined influence of comorbidity and cancer on patients’ quality of life.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.