Molecules | |
CAPE Analogs Induce Growth Arrest and Apoptosis in Breast Cancer Cells | |
Annie-Pier Beauregard2  Jason Harquail2  Grégoire Lassalle-Claux2  Mehdi Belbraouet2  Jacques Jean-Francois2  Mohamed Touaibia2  Gilles A. Robichaud2  Jean Jacques Vanden Eynde1  | |
[1]Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB E1A 3E9, Canada | |
[2] | |
[3]Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB E1A 3E9, Canada | |
[4] E-Mails: | |
关键词: breast cancer; CAPE; apoptosis; NFκB; p53; caspase; | |
DOI : 10.3390/molecules200712576 | |
来源: mdpi | |
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【 摘 要 】
Breast cancer is the second leading cause of death amongst women worldwide. As a result, many have turned their attention to new alternative approaches to treat this disease. Caffeic acid phenylethyl ester (CAPE), a well-known active compound from bee propolis, has been previously identified as a strong antioxidant, anti-inflammatory, antiviral and anticancer molecule. In fact, CAPE is well documented as inducing cell death by inhibiting NFκB and by inducing pro-apoptotic pathways (
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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