Quantitative 1H-NMR Method for the Determination of Tadalafil in Bulk Drugs and its Tablets

Molecules

Qingyun Yang²  Hui Qiu²  Wei Guo²  Dongmei Wang²  Xingning Zhou²  Dan Xue²  Jinlan Zhang²  Song Wu¹  Yinghong Wang¹ 

[1] Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical Colledge, Beijing 100050, China;

关键词: tadalafil;    quantitative analysis;    quantitative proton nuclear magnetic resonance;    2;    4-dinitrotoluene;   

DOI  :  10.3390/molecules200712114

来源: mdpi

【 摘 要 】

A simple, rapid, accurate, and selective quantitative nuclear magnetic resonance method for the determination of tadalafil in bulk drugs and its tablets was established and evaluated. Spectra were obtained in dimethylsulfoxide-d₆ using 2,4-dinitrotoluene as the internal standard. In this study, the method’s linearity, range, limit of quantification, stability, precision, and accuracy were validated. The results were consistent with those obtained from high-performance liquid chromatography analysis. Thus, the proposed method is a useful and practical tool for the determination of tadalafil in bulk drugs and its tablets.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.