Early Events in Chikungunya Virus Infection—From Virus Cell Binding to Membrane Fusion

Viruses

Mareike K. S. van Duijl-Richter²  Tabitha E. Hoornweg²  Izabela A. Rodenhuis-Zybert²  Jolanda M. Smit¹  Yorgo Modis² 

[1] Department of Medical Microbiology, University of Groningen and University Medical Center Groningen, 9700 RB Groningen, The Netherlands;

关键词: Chikungunya virus;    alphavirus;    cell tropism;    receptor;    entry;    endocytosis;    clathrin;    fusion;    neutralizing antibodies;    entry inhibitors;   

DOI  :  10.3390/v7072792

来源: mdpi

【 摘 要 】

Chikungunya virus (CHIKV) is a rapidly emerging mosquito-borne alphavirus causing millions of infections in the tropical and subtropical regions of the world. CHIKV infection often leads to an acute self-limited febrile illness with debilitating myalgia and arthralgia. A potential long-term complication of CHIKV infection is severe joint pain, which can last for months to years. There are no vaccines or specific therapeutics available to prevent or treat infection. This review describes the critical steps in CHIKV cell entry. We summarize the latest studies on the virus-cell tropism, virus-receptor binding, internalization, membrane fusion and review the molecules and compounds that have been described to interfere with virus cell entry. The aim of the review is to give the reader a state-of-the-art overview on CHIKV cell entry and to provide an outlook on potential new avenues in CHIKV research.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.