Latest Insights into Marek’s Disease Virus Pathogenesis and Tumorigenesis

Cancers

AndeléM. Conradie¹  Yu You¹  BenediktB. Kaufer¹  LucaD. Bertzbach¹ 

[1] Institut für Virologie, Zentrum für Infektionsmedizin, Freie Universität Berlin, Robert-von-Ostertag-Straße 7-13, 14163 Berlin, Germany;

关键词: lymphoma;    avian cancer;    herpesvirus;    marek’s disease virus;    vaccine;    life cycle;    cell tropism;   

DOI  :  10.3390/cancers12030647

来源: DOAJ

【 摘 要 】

Marek’s disease virus (MDV) infects chickens and causes one of the most frequent cancers in animals. Over 100 years of research on this oncogenic alphaherpesvirus has led to a profound understanding of virus-induced tumor development. Live-attenuated vaccines against MDV were the first that prevented cancer and minimized the losses in the poultry industry. Even though the current gold standard vaccine efficiently protects against clinical disease, the virus continuously evolves towards higher virulence. Emerging field strains were able to overcome the protection provided by the previous two vaccine generations. Research over the last few years revealed important insights into the virus life cycle, cellular tropism, and tumor development that are summarized in this review. In addition, we discuss recent data on the MDV transcriptome, the constant evolution of this highly oncogenic virus towards higher virulence, and future perspectives in MDV research.

【 授权许可】

Unknown