Red Algae (Rhodophyta) from the Coast of Madagascar: Preliminary Bioactivity Studies and Isolation of Natural Products

Marine Drugs

Marie Pascaline Rahelivao¹  Margit Gruner¹  Hanta Andriamanantoanina²  Bakolinirina Andriamihaja³  Ingmar Bauer¹  Hans-Joachim Knölker¹ 

[1] Department Chemie, Technische Universität Dresden, Bergstr. 66, 01069 Dresden, Germany; E-Mails:;Centre National de Recherche sur l’Environnement, MESupRes, BP 1739, Antananarivo 101, Madagascar; E-Mail:;Laboratoire de Chimie Appliquée aux Substances Naturelles, Faculté des Sciences, Université d’Antananarivo, BP 566, Antananarivo 101, Madagascar; E-Mail:

关键词: algae;    indole alkaloids;    steroids;    NMR spectroscopy;    antimicrobial activity;   

DOI  :  10.3390/md13074197

来源: mdpi

【 摘 要 】

Several species of red algae (Rhodophyta) from the coastal regions of Madagascar have been investigated for their natural products. The most abundant compound was cholesterol (5) in combination with a series of oxidized congeners. The brominated indoles 1–3 along with the sesquiterpene debilone (4) have been isolated from Laurencia complanata. For the first time, debilone (4) has been obtained from a marine plant. From the methanol extract of Calloseris sp., we have achieved the second isolation of the unusual A-ring contracted steroids (−)-2-ethoxycarbonyl-2β-hydroxy-A-nor-cholest-5-en-4-one (9) and phorbasterone B (10). The crude extracts of Laurencia complanata exhibited antimicrobial activity against Bacillus cereus, Staphylococcus aureus, Streptococcus pneumoniae, and Candida albicans.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.