Two New Koumine-Type Indole Alkaloids fromGelsemium elegans Benth.

Molecules

Mingxue Sun¹  Xiaoli Hou¹  Huanhuan Gao¹  Junsheng Guo¹ 

[1] ¹Lab of Toxicology and Pharmacology, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China ²Department of Military Hygiene, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China

关键词: indole alkaloids;    Gelsemium elegans Benth.;    21-oxokoumine;    furanokoumine;   

DOI  :  10.3390/molecules18021819

来源: mdpi

【 摘 要 】

Two new indole alkaloids, 21-oxokoumine (1) and furanokoumine (2), were isolated from the roots of Gelsemium elegans Benth together with three known compounds. The structures of the two novel compounds were elucidated by spectroscopic methods, including NMR, HR-ESI-MS, UV, IR, CD and molecular modeling. Compound 1 is the first instance of a koumine-type alkaloid with a carbonyl at the C-21 position, while compound 2 possesses a tetrahydrofuran ring located on C-20 and C-21.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.