International Journal of Molecular Sciences | |
Prognostic Value of Preoperative Serum Levels of Periostin (PN) in Early Breast Cancer (BCa) | |
Pier Vitale Nuzzo2  Alessandra Rubagotti2  Francesca Argellati2  Antonio Di Meglio2  Elisa Zanardi2  Linda Zinoli2  Paola Comite1  Michele Mussap1  Francesco Boccardo2  | |
[1] Department of Laboratory Medicine, IRCCS San Martino University Hospital—IST National Cancer Research Institute Largo Rosanna Benzi 10, 16132 Genoa, Italy; E-Mails:;Academic Unit of Medical Oncology, IRCCS San Martino University Hospital—IST National Cancer Research Institute, Largo Rosanna Benzi 10, 16132 Genoa, Italy; E-Mails: | |
关键词: periostin protein; breast neoplasms; extracellular matrix proteins; prognosis; biomarkers; enzyme-linked immunosorbent assay; | |
DOI : 10.3390/ijms160817181 | |
来源: mdpi | |
【 摘 要 】
PN is a secreted cell adhesion protein critical for carcinogenesis. Elevated serum levels of PN have been implicated as playing an important role in different types of cancer, and a few reports suggest a potential role as a prognostic marker. We evaluated the prognostic significance of preoperative serum PN concentration in patients with BCa receiving curative surgery. Enzyme-Linked Immunosorbent Assay (ELISA) was performed to determine the preoperative serum PN level in 182 patients. The correlations between serum PN concentration with clinical pathological features and PN expression in primary tumor samples were analyzed. The prognostic impact of serum PN levels with all-cause and BCa-specific mortality was also investigated. Appropriate statistics were used. Elevated serum PN levels were significantly associated with patient age (
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
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