Prognostic Value of Preoperative Serum Levels of Periostin (PN) in Early Breast Cancer (BCa)

International Journal of Molecular Sciences

Pier Vitale Nuzzo²  Alessandra Rubagotti²  Francesca Argellati²  Antonio Di Meglio²  Elisa Zanardi²  Linda Zinoli²  Paola Comite¹  Michele Mussap¹  Francesco Boccardo² 

[1] Department of Laboratory Medicine, IRCCS San Martino University Hospital—IST National Cancer Research Institute Largo Rosanna Benzi 10, 16132 Genoa, Italy; E-Mails:;Academic Unit of Medical Oncology, IRCCS San Martino University Hospital—IST National Cancer Research Institute, Largo Rosanna Benzi 10, 16132 Genoa, Italy; E-Mails:

关键词: periostin protein;    breast neoplasms;    extracellular matrix proteins;    prognosis;    biomarkers;    enzyme-linked immunosorbent assay;   

DOI  :  10.3390/ijms160817181

来源: mdpi

【 摘 要 】

PN is a secreted cell adhesion protein critical for carcinogenesis. Elevated serum levels of PN have been implicated as playing an important role in different types of cancer, and a few reports suggest a potential role as a prognostic marker. We evaluated the prognostic significance of preoperative serum PN concentration in patients with BCa receiving curative surgery. Enzyme-Linked Immunosorbent Assay (ELISA) was performed to determine the preoperative serum PN level in 182 patients. The correlations between serum PN concentration with clinical pathological features and PN expression in primary tumor samples were analyzed. The prognostic impact of serum PN levels with all-cause and BCa-specific mortality was also investigated. Appropriate statistics were used. Elevated serum PN levels were significantly associated with patient age (p = 0.005), adjuvant systemic therapy (p = 0.04) and progesterone receptor (PgR) status (p = 0.02). No correlation between PN preoperative serum levels and other clinical-pathological parameters, including either the epithelial or the stromal PN expression of primary tumor or the combination of the two, was found. Similarly, no association between serum PN levels and either all-cause or BCa-specific mortality was found. However, subgroup analysis revealed a correlation between higher PN serum levels and all-cause mortality in patients with node-negative disease (p = 0.05) and in those with a low PgR expression (p = 0.03). Higher levels of serum PN were also found to correlate with BCa-specific mortality in the subgroup of patients who did not receive any adjuvant systemic therapy (p = 0.04). Our findings suggest that PN was detectable in the serum of early BCa patients before surgery and increased base-line serum levels predicted worse long-term survival outcomes in specific subgroups of patients.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.