Cyclic GMP and Cilia Motility

Cells

Todd A. Wyatt¹  Gang Dong² 

[1] VA Nebraska-Western Iowa Health Care System, Research Service, Department of Veterans Affairs Medical Center, 4101 Woolworth Avenue, Omaha, NE 68105, USA;id="af1-cells-04-00315">1VA Nebraska-Western Iowa Health Care System, Research Service, Department of Veterans Affairs Medical Center, 4101 Woolworth Avenue, Omaha, NE 68105, U

关键词: cilia;    cGMP;    signal transduction;    history;    review;   

DOI  :  10.3390/cells4030315

来源: mdpi

【 摘 要 】

Motile cilia of the lungs respond to environmental challenges by increasing their ciliary beat frequency in order to enhance mucociliary clearance as a fundamental tenant of innate defense. One important second messenger in transducing the regulable nature of motile cilia is cyclic guanosine 3′,5′-monophosphate (cGMP). In this review, the history of cGMP action is presented and a survey of the existing data addressing cGMP action in ciliary motility is presented. Nitric oxide (NO)-mediated regulation of cGMP in ciliated cells is presented in the context of alcohol-induced cilia function and dysfunction.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.