Unveiling the Mode of Action of Two Antibacterial Tanshinone Derivatives

International Journal of Molecular Sciences

Dongdong Wang²  Wuxia Zhang²  Tingting Wang²  Na Li²  Haibo Mu²  Jiwen Zhang²  Jinyou Duan¹ 

[1] College of Science, Northwest A&F University, Yangling 712100, Shaanxi, China;

关键词: tanshinone;    pyrrolidine;    antibacterial;    reactive oxygen species (ROS);    membrane;   

DOI  :  10.3390/ijms160817668

来源: mdpi

【 摘 要 】

In this study, 2-(N-pyrrolidine-alkyl) tanshinones bearing pyrrolidine groups were synthesized and the antibacterial mechanism was explored. These derivatives selectively elicited antibacterial activity against Gram-positive bacteria. Moreover, their antibacterial activities were time-, concentration-dependent and persistent. It appeared that Fenton-mediated hydroxyl radicals were involved, and the disruption of cell membranes was observed. This study indicates that 2-(N-pyrrolidine-alkyl) tanshinones might be potential candidates as antibacterial agents.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.