Inhibiting Microbial Toxins Using Plant-Derived Compounds and Plant Extracts

Medicines

Abhinav Upadhyay²  Shankumar Mooyottu²  Hsinbai Yin²  Meera Surendran Nair²  Varunkumar Bhattaram²  Kumar Venkitanarayanan¹ 

[1] Department of Animal Science, University of Connecticut, Storrs, CT 06269, USA;

关键词: plant-derived compounds;    plant extracts;    bacterial toxins;    mycotoxins;    toxin inhibition;    anti-virulence strategies;   

DOI  :  10.3390/medicines2030186

来源: mdpi

【 摘 要 】

Many pathogenic bacteria and fungi produce potentially lethal toxins that cause cytotoxicity or impaired cellular function either at the site of colonization or other locations in the body through receptor-mediated interactions. Various factors, including biotic and abiotic environments, competing microbes, and chemical cues affect toxin expression in these pathogens. Recent work suggests that several natural compounds can modulate toxin production in pathogenic microbes. However, studies explaining the mechanistic basis for their effect are scanty. This review discusses the potential of various plant-derived compounds for reducing toxin production in foodborne and other microbes. In addition, studies highlighting their anti-toxigenic mechanism(s) are discussed.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.