Palladium-Catalyzed One-Pot Approach to 3-(Diarylmethylene)oxindoles from Propiolamidoaryl Triflate

Molecules

Dahye Lee¹  Sunhwa Park¹  Yoseb Yu²  Kye Jung Shin²  Jae Hong Seo¹ 

[1] Integrated Research Institute of Pharmaceutical Sciences, College of Pharmacy, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 420-743, Korea;

关键词: 3-(Diarylmethylene)oxindole;    one-pot reaction;    aryl triflate;    palladium-catalyzed reaction;   

DOI  :  10.3390/molecules200814022

来源: mdpi

【 摘 要 】

3-(Diarylmethylene)oxindoles have been synthesized from propiolamidoaryl triflate utilizing a palladium-catalyzed one-pot reaction consisting of three successive reactions: Sonogashira, Heck, and Suzuki-Miyaura. This method allows for the production of a complex skeleton of 3-(diarylmethylene)oxindole from propiolamidoaryl triflate using a commercially available aryl iodide and arylboronic acid in a simple and efficient way with moderate yield and stereoselectivity.

【 授权许可】

CC BY   
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