A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi

Marine Drugs

Yan-Ting Wang²  Ya-Rong Xue²  Chang-Hong Liu¹ 

[1] State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University; 163 Xianlin Avenue, Nanjing 210023, Jiangsu, China;

关键词: deep-sea fungi;    bioactive compounds;    anticancer;    antimicrobial;    antiviral;    antifungal;   

DOI  :  10.3390/md13084594

来源: mdpi

【 摘 要 】

Deep-sea fungi, the fungi that inhabit the sea and the sediment at depths of over 1000 m below the surface, have become an important source of industrial, agricultural, and nutraceutical compounds based on their diversities in both structure and function. Since the first study of deep-sea fungi in the Atlantic Ocean at a depth of 4450 m was conducted approximately 50 years ago, hundreds of isolates of deep-sea fungi have been reported based on culture-dependent methods. To date more than 180 bioactive secondary metabolites derived from deep-sea fungi have been documented in the literature. These include compounds with anticancer, antimicrobial, antifungal, antiprotozoal, and antiviral activities. In this review, we summarize the structures and bioactivities of these metabolites to provide help for novel drug development.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.