Anticancer Properties of Curcumin Against Colorectal Cancer: A Review

Frontiers in Oncology

Carlos Adam Conte-Junior¹  Adebola Busola Ojo²  Clara Mariana Goncalves Lima³  Gaber El-Saber Batiha⁴  Bukola Atunwa⁵  Gomaa Mostafa-Hedeab⁷  Oluwafemi Adeleke Ojo⁸  Damilare Rotimi⁹  Matthew Eboseremen Iyobhebhe⁹  Tobiloba Christiana Elebiyo⁹  Temiloluwa Rhoda Adeyemo⁹ 

[1] Center for Food Analysis (NAL), Technological Development Support Laboratory (LADETED), Federal University of Rio de Janeiro (UFRJ), Cidade Universitaria, Rio de Janeiro, Brazil;Department of Biochemistry, Ekiti State University, Ado-Ekiti, Nigeria;Department of Food Science , Federal University of Lavras, Minas Gerais, Brazil;Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt;Department of Physical Sciences, Chemistry Unit, Landmark University, Omu-Aran, Nigeria;Pharmacology Department and Health Research Unit, Medical College, Jouf University, Sakaka, Saudi Arabia;Pharmacology Department, Faculty of Medicine, Beni-Suef University, Beni Suef, Egypt;Phytomedicine, Molecular Toxicology, and Computational Biochemistry Research Laboratories, Department of Biochemistry, Bowen University, Iwo, Nigeria;Phytomedicine, Molecular Toxicology, and Computational Biochemistry Research Laboratories, Department of Biochemistry, Landmark University, Omu-Aran, Nigeria;

关键词: curcumin;    colorectal cancer;    pharmacological activities;    bioactive compounds;    anticancer;   

DOI  :  10.3389/fonc.2022.881641

来源: DOAJ

【 摘 要 】

Colorectal cancer (CRC) is one of the most common and reoccurring diseases, as well as the world’s second largest cause of mortality. Despite existing preventative, diagnostic, and treatment methods, such as chemotherapy, the number of instances rises year after year. As a result, new effective medications targeting specific checkpoints should be developed to combat CRC. Natural compounds, such as curcumin, have shown significant anti-colorectal cancer characteristics among medications that can be used to treat CRC. These chemicals are phenolic compounds that belong to the curcuminoids category. Curcumin exerts its anti-proliferative properties against CRC cell lines in vitro and in vivo via a variety of mechanisms, including the suppression of intrinsic and extrinsic apoptotic signaling pathways, the stoppage of the cell cycle, and the activation of autophagy. Curcumin also has anti-angiogenesis properties. Thus, this review is aimed at emphasizing the biological effect and mode of action of curcumin on CRC. Furthermore, the critical role of these substances in CRC chemoprevention was emphasized.

【 授权许可】

Unknown