Human Leukocyte Antigen Class II Alleles Are Associated with Hepatitis C Virus Natural Susceptibility in the Chinese Population

International Journal of Molecular Sciences

Ming Yue¹  Ke Xu²  Meng-Ping Wu⁴  Ya-Ping Han¹  Peng Huang⁴  Zhi-Hang Peng⁴  Jie Wang³  Jing Su⁴  Rong-Bin Yu⁴  Jun Li¹  Yun Zhang⁴ 

[1]Department of Infectious Diseases, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

[2] E-Mails:

[3]Department of Acute Infection Diseases, Jiangsu Province Center for Disease Prevention and Control, Nanjing 210009, China

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[5]School of Nursing, Nanjing Medical University, Nanjing 211166, China

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[7]Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China

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关键词: human leukocyte antigen;    hepatitis C virus;    infection;    polymorphism;    outcome;   

DOI  :  10.3390/ijms160816792

来源: mdpi

【 摘 要 】

Human leukocyte antigen (HLA) class II molecule influences host antigen presentation and anti-viral immune response. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) within HLA class II gene were associated with different clinical outcomes of hepatitis C virus (HCV) infection. Three HLA class II SNPs (rs3077, rs2395309 and rs2856718) were genotyped by TaqMan assay among Chinese population, including 350 persistent HCV infection patients, 194 spontaneous viral clearance subjects and 973 HCV-uninfected control subjects. After logistic regression analysis, the results indicated that the rs2856718 TC genotype was significantly associated with the protective effect of the HCV natural susceptibility (adjusted OR: 0.712, 95% CI: 0.554–0.914) when compared with reference TT genotype, and this remained significant after false discovery rate (FDR) correction (p = 0.024). Moreover, the protective effect of rs2856718 was observed in dominant genetic models (adjusted OR: 0.726, 95% CI: 0.574–0.920), and this remained significant after FDR correction (p = 0.024). In stratified analysis, a significant decreased risk was found in rs2856718C allele in the male subgroup (adjusted OR: 0.778, 95% CI: 0.627–0.966) and hemodialysis subgroup (adjusted OR: 0.713, 95% CI: 0.552–0.921). Our results indicated that the genetic variations of rs2856718 within the HLA-DQ gene are associated with the natural susceptibility to HCV infection among the Chinese population.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.