Interleukin-17A Gene Expression in Morbidly Obese Women

International Journal of Molecular Sciences

Fernando Zapata-Gonzalez¹  Teresa Auguet¹  Gemma Aragonès¹  Esther Guiu-Jurado¹  Alba Berlanga¹  Salomé Martinez⁵  Andreu Martí³  Fátima Sabench⁴  Mercé Hernandez⁴  Carmen Aguilar¹  Joan Josep Sirvent⁵  Rosa Jorba²  Daniel Del Castillo⁴  Cristl Richart¹ 

[1] Grup de Recerca GEMMAIR (AGAUR)—Medicina Aplicada, Departament de Medicina i Cirurgia, Institut d’Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili (URV), 43007 Tarragona, Spain; E-Mails:;Servei de Cirurgia, Hospital Universitari Joan XXIII Tarragona, Mallafré Guasch, 4, 43007 Tarragona, Spain; E-Mail:;Servei Medicina Interna, Hospital Universitari Joan XXIII Tarragona, Mallafré Guasch, 4, 43007 Tarragona, Spain; E-Mail:;Servei de Cirurgia, Hospital Sant Joan de Reus, Departament de Medicina i Cirurgia, IISPV, Universitat Rovira i Virgili (URV), Avinguda Doctor Josep Laporte, 2, 43204 Tarragona, Spain; E-Mails:;Servei Anatomia Patològica, Hospital Universitari Joan XXIII Tarragona, Mallafré Guasch, 4, 43007 Tarragona, Spain; E-Mails:

关键词: IL-17A;    morbid obesity;    adipo/cytokine;    visceral adipose tissue;   

DOI  :  10.3390/ijms160817469

来源: mdpi

【 摘 要 】

Data from recent studies conducted in rodent models and humans suggest that interleukin-17A (IL-17A) plays a role in the induction of inflammation in adipose tissue during obesity. The aim of this study was to assess the gene expression of IL-17A in adipose tissue of morbidly obese patients. We used RT-PCR to evaluate the expression of IL-17A and several adipo/cytokines in the visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) of 10 normal-weight control women (BMI < 25 kg/m²) and 30 morbidly obese women (MO, BMI > 40 kg/m²). We measured serum levels of IL-17A and adipo/cytokines in MO and normal weight women. IL-17A expression was significantly higher in VAT than in SAT in MO patients (p = 0.0127). It was very low in normal-weight controls in both VAT and SAT tissues. We found positive correlations between IL-17A and IL-6, lipocalin-2 and resistin in VAT of MO patients. The circulating level of IL-17A was higher in the normal-weight group than the MO patients (p = 0.032), and it was significantly related to adiponectin and TNFRII levels. In conclusion, IL-17A expression in VAT is increased in morbidly obese women, which suggests a link between obesity and innate immunity in low-grade chronic inflammation in morbidly obese women.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.