Interactions between Autophagy and Bacterial Toxins: Targets for Therapy?

Toxins

Jacques Mathieu¹ 

[1] Department of Microbiology, Institut de Recherche Biomédicale des Armées (IRBA), BP 73, Bretigny-sur-orge cedex F-91223, France; E-Mail:

关键词: bacterial toxins;    autophagy;    cyclic AMP;    therapeutic targets;   

DOI  :  10.3390/toxins7082918

来源: mdpi

【 摘 要 】

Autophagy is a physiological process involved in defense mechanisms for clearing intracellular bacteria. The autophagic pathway is finely regulated and bacterial toxins interact with this process in a complex manner. Bacterial toxins also interact significantly with many biochemical processes. Evaluations of the effects of bacterial toxins, such as endotoxins, pore-forming toxins and adenylate cyclases, on autophagy could support the development of new strategies for counteracting bacterial pathogenicity. Treatment strategies could focus on drugs that enhance autophagic processes to improve the clearance of intracellular bacteria. However, further in vivo studies are required to decipher the upregulation of autophagy and potential side effects limiting such approaches. The capacity of autophagy activation strategies to improve the outcome of antibiotic treatment should be investigated in the future.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.