Small Wonders—The Use of Nanoparticles for Delivering Antigen

Vaccines

Aya Taki²  Peter Smooker¹ 

[1] School of Applied Sciences, RMIT University, P.O. Box 71 Bundoora, Victoria 3083, Australia; E-Mail

关键词: nanoparticle;    antigen delivery;    templating system;    adjuvant;   

DOI  :  10.3390/vaccines3030638

来源: mdpi

【 摘 要 】

Despite the discovery of many potential antigens for subunit vaccines, universal protection is often lacking due to the limitations of conventional delivery methods. Subunit vaccines primarily induce antibody-mediated humoral responses, whereas potent antigen-specific cellular responses are required for prevention against some pathogenic infections. Nanoparticles have been utilised in nanomedicine and are promising candidates for vaccine or drug delivery. Nanoparticle vehicles have been demonstrated to be efficiently taken up by dendritic cells and induce humoral and cellular responses. This review provides an overview of nanoparticle vaccine development; in particular, the preparation of nanoparticles using a templating technique is highlighted, which would alleviate some of the disadvantages of existing nanoparticles. We will also explore the cellular fate of nanoparticle vaccines. Nanoparticle-based antigen delivery systems have the potential to develop new generation vaccines against currently unpreventable infectious diseases.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.