A New Ionone Glycoside and Three New Rhemaneolignans from the Roots of Rehmannia glutinosa

Molecules

Meng Li¹  Xiaolan Wang²  Xiaoke Zheng²  Jianchao Wang²  Wei Zhao²  Kai Song²  Xuan Zhao²  Yanli Zhang²  Haixue Kuang¹  Weisheng Feng² 

[1] School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China; E-Mails:;Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Zhengzhou 450046, China; E-Mails:

关键词: Rehmannia glutinosa;    ionone glycoside;    rhemaneolignans;    the protective effects of cardiomyocytes;   

DOI  :  10.3390/molecules200815192

来源: mdpi

【 摘 要 】

A new ionone glycoside, frehmaglutoside I (1), and three new rhemaneolignans A–C (2–4) were isolated from the 95% EtOH extract of the roots of Rehmannia glutinosa. Their structures were determined by extensive spectroscopic (UV, IR, HR-ESI-MS, 1D and 2D NMR) analyses. In addition, these compounds were evaluated for their protective effects on cardiocytes impaired by doxorubicin in H9c2 cells. Among them, compounds 1–3 exhibited protective effects against DOX-induced cardiotoxicity.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.