期刊论文详细信息
Molecules
A New Ionone Glycoside and Three New Rhemaneolignans from the Roots of Rehmannia glutinosa
Meng Li1  Xiaolan Wang2  Xiaoke Zheng2  Jianchao Wang2  Wei Zhao2  Kai Song2  Xuan Zhao2  Yanli Zhang2  Haixue Kuang1  Weisheng Feng2 
[1] School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China; E-Mails:;Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Zhengzhou 450046, China; E-Mails:
关键词: Rehmannia glutinosa;    ionone glycoside;    rhemaneolignans;    the protective effects of cardiomyocytes;   
DOI  :  10.3390/molecules200815192
来源: mdpi
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【 摘 要 】

A new ionone glycoside, frehmaglutoside I (1), and three new rhemaneolignans AC (24) were isolated from the 95% EtOH extract of the roots of Rehmannia glutinosa. Their structures were determined by extensive spectroscopic (UV, IR, HR-ESI-MS, 1D and 2D NMR) analyses. In addition, these compounds were evaluated for their protective effects on cardiocytes impaired by doxorubicin in H9c2 cells. Among them, compounds 13 exhibited protective effects against DOX-induced cardiotoxicity.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.

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