期刊论文详细信息
Molecules | |
Synthesis of Novel 2,5-Disubstituted-1,3,4-thiadiazoles Clubbed 1,2,4-Triazole, 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and/or Schiff Base as Potential Antimicrobial and Antiproliferative Agents | |
Nadjet Rezki2  Amjad M. Al-Yahyawi2  Sanaa K. Bardaweel1  Fawzia F. Al-Blewi2  Mohamed R. Aouad2  | |
[1] Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman 11942, Jordan; E-Mail:;Department of Chemistry, Faculty of Sciences, Taibah University, P. O. Box 344, Al-Madinah Al-Munawarah 30002, Saudi Arabia; E-Mails: | |
关键词: 1; 3; 4-thiadiazole; 1; 2; 4-triazole; 1; 3; 4-oxadiazole; Schiff base; antimicrobial activity; antitumor activity; | |
DOI : 10.3390/molecules200916048 | |
来源: mdpi | |
【 摘 要 】
In the present study, a new series of 2,5-disubstituted-1,3,4-thiadiazole tethered 1,2,4-triazole, 1,3,4-thiadiazole, 1,3,4-oxadiazole and Schiff base derivatives were synthesized and characterized by IR, 1H-NMR, 13C-NMR, MS and elemental analyses. All compounds were screened for their antibacterial, antifungal and antiproliferative activity. Some of the synthesized derivatives have displayed promising biological activity.
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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