Synthesis of Novel 2,5-Disubstituted-1,3,4-thiadiazoles Clubbed 1,2,4-Triazole, 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and/or Schiff Base as Potential Antimicrobial and Antiproliferative Agents

Molecules

Nadjet Rezki²  Amjad M. Al-Yahyawi²  Sanaa K. Bardaweel¹  Fawzia F. Al-Blewi²  Mohamed R. Aouad² 

[1] Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman 11942, Jordan; E-Mail:;Department of Chemistry, Faculty of Sciences, Taibah University, P. O. Box 344, Al-Madinah Al-Munawarah 30002, Saudi Arabia; E-Mails:

关键词: 1;    3;    4-thiadiazole;    1;    2;    4-triazole;    1;    3;    4-oxadiazole;    Schiff base;    antimicrobial activity;    antitumor activity;   

DOI  :  10.3390/molecules200916048

来源: mdpi

【 摘 要 】

In the present study, a new series of 2,5-disubstituted-1,3,4-thiadiazole tethered 1,2,4-triazole, 1,3,4-thiadiazole, 1,3,4-oxadiazole and Schiff base derivatives were synthesized and characterized by IR, ¹H-NMR, ¹³C-NMR, MS and elemental analyses. All compounds were screened for their antibacterial, antifungal and antiproliferative activity. Some of the synthesized derivatives have displayed promising biological activity.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.