Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole Derivatives

Molecules

Thoraya A. Farghaly¹  Magda A. Abdallah¹ 

[1] Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt

关键词: antimicrobial activity;    enaminone;    1;    3;    4-thiadiazole;    hydrazonoyl halides;   

DOI  :  10.3390/molecules171214625

来源: mdpi

【 摘 要 】

New series of 1,3,4-thiadiazoles have been prepared via reaction of 1,3,4-thiadiazolenaminones 1 with N-phenyl 2-oxopropanehydrazonoyl chloride (2) in dioxane in the presence of triethylamine. Also, some new heterocycles incorporating 1,3,4-thiadiazole ring were obtained by reaction of 1,3,4-thiadiazolenaminones 1 with nitrogen-nucleophiles like hydrazine hydrate, 3-amino-1,2,4-triazole and 2-aminobenzimidazole. The structure of the new products was established based on elemental and spectral analysis. The relation between the structure of the products and their activity towards some microorganisms was studied and promising results were obtained.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.