The Role of Skin Barrier in the Pathogenesis of Food Allergy

Children

Neema Izadi³  Minnelly Luu²  Peck Y. Ong¹  Jonathan S. Tam¹ 

[1] Division of Clinical Immunology and Allergy, Department of Pediatrics, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California; Los Angeles, CA 90027, USA; E-Mail:;Department of Dermatology, Keck School of Medicine, University of Southern California; Los Angeles, CA 90033, USA; E-mail:;Department of Pediatrics, Children’s Hospital Los Angeles, Los Angeles, CA 90027, USA; E-Mail:

关键词: food allergy;    skin barrier;    allergic sensitization;    filaggrin;   

DOI  :  10.3390/children2030382

来源: mdpi

【 摘 要 】

Food allergy is a serious public health problem with an increasing prevalence. Current management is limited to food avoidance and emergency treatment. Research into the pathogenesis of food allergy has helped to shape our understanding of how patients become sensitized to an allergen. Classically, food sensitization was thought to occur through the gastrointestinal tract, but alternative routes of sensitization are being explored, specifically through the skin. Damaged skin barrier may play a crucial role in the development of food sensitization. Better understanding of how patients initially become sensitized may help lead to the development of a safe and effective treatment for food allergies or better prevention strategies.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.