IgE sensitization in relation to preschool eczema and filaggrin mutation

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:140

Article

Johansson, Emma Kristin^1,2  Bergstrom, Anna⁵  Kull, Inger^3,4  Lind, Tomas^8,9  Soderhall, Cilla^6,7  van Hage, Marianne^10,11  Wickman, Magnus^4,5  Ballardini, Natalia^4,5,12  Wahlgren, Carl-Fredrik^1,13 

[1] Karolinska Inst, Dermatol & Venereol Unit, Dept Med Solna, Stockholm, Sweden

[2] Soder Sjukhuset, Dermatol & Venereal Clin, Sjukhusbacken 10, SE-11883 Stockholm, Sweden

[3] Soder Sjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden

[4] Soder Sjukhuset, Sachs Children & Youth Hosp, Stockholm, Sweden

[5] Karolinska Inst, Inst Environm Med, Stockholm, Sweden

[6] Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden

[7] Karolinska Inst, Dept Biosci & Nutr, Stockholm, Sweden

[8] Stockholm Cty Council, Dept Occupat & Environm Med, Stockholm, Sweden

[9] Karolinska Inst, Inst Environm Med, Environm Epidemiol Unit, Stockholm, Sweden

[10] Karolinska Inst, Dept Med Solna, Immunol & Allergy Unit, Stockholm, Sweden

[11] Karolinska Univ Hosp, Stockholm, Sweden

[12] Kings Coll London, St Johns Inst Dermatol, London, England

[13] Karolinska Univ Hosp Solna, Dept Dermatol, Stockholm, Sweden

关键词: Allergens;    atopic dermatitis;    birth cohort;    filaggrin;    food allergy;    IgE;    peanut;    population;    sensitization;    skin barrier;   

DOI  :  10.1016/j.jaci.2017.04.008

来源: Elsevier

【 摘 要 】

Background: Eczema (atopic dermatitis) is associated with an increased risk of having IgE antibodies. IgE sensitization can occur through an impaired skin barrier. Filaggrin gene (FLG) mutation is associated with eczema and possibly also with IgE sensitization. Objective: We sought to explore the longitudinal relation between preschool eczema (PSE), FLG mutation, or both and IgE sensitization in childhood. Methods: A total of 3201 children from the BAMSE (Children Allergy Milieu Stockholm Epidemiology) birth cohort recruited from the general population were included. Regular parental questionnaires identified children with eczema. Blood samples were collected at 4, 8, and 16 years of age for analysis of specific IgE. FLG mutation analysis was performed on 1890 of the children. Results: PSE was associated with IgE sensitization to both food allergens and aeroallergens up to age 16 years (overall adjusted odds ratio, 2.30; 95% CI, 2.00-2.66). This association was even stronger among children with persistent PSE. FLG mutation was associated with IgE sensitization to peanut at age 4 years (adjusted odds ratio, 1.88; 95% CI, 1.03-3.44) but not to other allergens up to age 16 years. FLG mutation and PSE were not effect modifiers for the association between IgE sensitization and PSE or FLG mutation, respectively. Sensitized children with PSE were characterized by means of polysensitization, but no other specific IgE sensitization patterns were found. Conclusions: PSE is associated with IgE sensitization to both food allergens and aeroallergens up to 16 years of age. FLG mutation is associated with IgE sensitization to peanut but not to other allergens. Sensitized children with preceding PSE are more often polysensitized.

【 授权许可】

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