Diagnostic Modalities for Invasive Mould Infections among Hematopoietic Stem Cell Transplant and Solid Organ Recipients: Performance Characteristics and Practical Roles in the Clinic

Journal of Fungi

Ghady Haidar¹  Bonnie A. Falcione¹  M. Hong Nguyen¹ 

[1] Department of Medicine, University of Pittsburgh Medical Center, Scaife Hall, Suite 871, 3550 Terrace Street, Pittsburgh, PA 15261, USA; E-Mails:

关键词: invasive mould infections;    aspergillosis;    solid organ transplant;    hematological malignancy;    hematopoietic stem cell transplant;    diagnostic biomarker;    galactomannan;    β-d-glucan;    PCR;   

DOI  :  10.3390/jof1020252

来源: mdpi

【 摘 要 】

The morbidity and mortality of hematopoietic stem cell and solid organ transplant patients with invasive fungal infections (IFIs) remain high despite an increase in the number of effective antifungal agents. Early diagnosis leading to timely administration of antifungal therapy has been linked to better outcomes. Unfortunately, the diagnosis of IFIs remains challenging. The current gold standard for diagnosis is a combination of histopathology and culture, for which the sensitivity is <50%. Over the past two decades, a plethora of non-culture-based antigen and molecular assays have been developed and clinically validated. In this article, we will review the performance of the current commercially available non-cultural diagnostics and discuss their practical roles in the clinic.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.