MiR-122 Induces Radiosensitization in Non-Small Cell Lung Cancer Cell Line

International Journal of Molecular Sciences

Debin Ma⁵  Hui Jia¹  Mengmeng Qin⁵  Wenjie Dai⁴  Tao Wang²  Erguang Liang²  Guofu Dong³  Zuojun Wang¹  Zhiyuan Zhang⁵  Fan Feng¹ 

[1] Department of Pharmacy, General Hospital of Shenyang Military Command, Shenyang 110016, China; E-Mails:;Institute of Toxicology and Pharmacology, Medicine Military Medical Science Academy of the Chinese PLA, Beijing 100850, China; E-Mails:;Institute of Radiation, Medicine Military Medical Science Academy of the Chinese PLA, Beijing 100850, China; E-Mail:;Department of Pharmacy, Beijing Chuiyangliu Hospital Affiliated to Tsinghua University, Beijing 100022, China; E-Mail:;Department of Respiratory Diseases, General Hospital of Shenyang Military Command, Shenyang 110016, China; E-Mails:

关键词: non-small cell lung cancer;    microrna122;    adenoviral vector;    ionizing radiation;    radiosensitization;   

DOI  :  10.3390/ijms160922137

来源: mdpi

【 摘 要 】

MiR-122 is a novel tumor suppresser and its expression induces cell cycle arrest, or apoptosis, and inhibits cell proliferation in multiple cancer cells, including non-small cell lung cancer (NSCLC) cells. Radioresistance of cancer cell leads to the major drawback of radiotherapy for NSCLC and the induction of radiosensitization could be a useful strategy to fix this problem. The present work investigates the function of miR-122 in inducing radiosensitization in A549 cell, a type of NSCLC cells. MiR-122 induces the radiosensitization of A549 cells. MiR-122 also boosts the inhibitory activity of ionizing radiation (IR) on cancer cell anchor-independent growth and invasion. Moreover, miR-122 reduced the expression of its targeted genes related to tumor-survival or cellular stress response. These results indicate that miR-122 would be a novel strategy for NSCLC radiation-therapy.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.