Rutin Increases Muscle Mitochondrial Biogenesis with AMPK Activation in High-Fat Diet-Induced Obese Rats

Nutrients

Sangjin Seo¹  Mak-Soon Lee¹  Eugene Chang¹  Yoonjin Shin¹  Soojung Oh¹  In-Hwan Kim² 

[1] Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 120-750, Korea; E-Mails:;Department of Food and Nutrition, Korea University, Seoul 136-703, Korea; E-Mail:

关键词: rutin;    obesity;    skeletal muscle;    mitochondria;    AMPK activity;   

DOI  :  10.3390/nu7095385

来源: mdpi

【 摘 要 】

Decreased mitochondrial number and dysfunction in skeletal muscle are associated with obesity and the progression of obesity-associated metabolic disorders. The specific aim of the current study was to investigate the effects of rutin on mitochondrial biogenesis in skeletal muscle of high-fat diet-induced obese rats. Supplementation with rutin reduced body weight and adipose tissue mass, despite equivalent energy intake (p < 0.05). Rutin significantly increased mitochondrial size and mitochondrial DNA (mtDNA) content as well as gene expression related to mitochondrial biogenesis, such as peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), nuclear respiratory factor-1 (NRF-1), transcription factor A (Tfam), and nicotinamide adenine dinucleotide (NAD)-dependent deacetylase, sirtulin1 (SIRT1) in skeletal muscle (p < 0.05). Moreover, rutin consumption increased muscle adenosine monophosphate-activated protein kinase (AMPK) activity by 40% (p < 0.05). Taken together, these results suggested at least partial involvement of muscle mitochondria and AMPK activation in the rutin-mediated beneficial effect on obesity.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.