Diterpenoids from the Endophytic Fungus Botryosphaeria sp. P483 of the Chinese Herbal Medicine Huperzia serrata

Molecules

Yan-Mei Chen¹  Yin-He Yang¹  Xiao-Nian Li¹  Cheng Zou²  Pei-Ji Zhao¹ 

[1] State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; E-Mails:;School of Pharmaceutical Sciences, Kunming Medical University, Kunming 650500, China; E-Mail:

关键词: Botryosphaeria sp. P483;    tetranorlabdane diterpenoid;    X-ray crystallography;    antifungal activity;    nematicidal activity;   

DOI  :  10.3390/molecules200916924

来源: mdpi

【 摘 要 】

Two new tetranorlabdane diterpenoids, named botryosphaerins G (1) and H (2), were isolated from the solid fermentation products of Botryosphaeria sp. P483 along with seven known tetranorlabdane diterpenes (3–9). Their structures were elucidated by extensive analysis, including 1D and 2D nuclear magnetic resonance (NMR) spectroscopy, and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). Their absolute configuration was confirmed by single-crystal X-ray diffraction analyses using the anomalous scattering of Cu Kα radiation. All of the isolated compounds were tested for activity against phytopathogenic fungi and nematodes. Compounds 2 and 3 showed antifungal activity and compound 2 showed weak nematicidal activity.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.