Chemical Composition Analysis, Antimicrobial Activity and Cytotoxicity Screening of Moss Extracts (Moss Phytochemistry)

Molecules

Laura Klavina³  Gunta Springe⁴  Vizma Nikolajeva¹  Illia Martsinkevich²  Ilva Nakurte²  Diana Dzabijeva²  Iveta Steinberga³ 

[1] Department of Microbiology and Biotechnology, University of Latvia, 4 Kronvalda Blvd., Riga LV-1010, Latvia; E-Mail:;Faculty of Chemistry, University of Latvia, 19 Raina Blvd., Riga LV-1586, Latvia; E-Mails:;Department of Environmental Science, University of Latvia, 19 Raina Blvd., Riga LV-1586, Latvia; E-Mail:;Institute of Biology, University of Latvia, 3 Miera Street, Salaspils LV-2169, Latvia; E-Mail:

关键词: extraction;    antiradical activity;    GC/MS;    LC-TOF-MS;    cytotoxicity;    antimicrobial activity;    polyphenols;    amino acids;   

DOI  :  10.3390/molecules200917221

来源: mdpi

【 摘 要 】

Mosses have been neglected as a study subject for a long time. Recent research shows that mosses contain remarkable and unique substances with high biological activity. The aim of this study, accordingly, was to analyze the composition of mosses and to screen their antimicrobial and anticancer activity. The total concentration of polyphenols and carbohydrates, the amount of dry residue and the radical scavenging activity were determined for a preliminary evaluation of the chemical composition of moss extracts. In order to analyze and identify the substances present in mosses, two types of extrahents (chloroform, ethanol) and the GC/MS and LC-TOF-MS methods were used. The antimicrobial activity was tested on four bacteria strains, and the anticancer activity on six cancer cell lines. The obtained results show the presence of a high number of primary (fatty acids and amino acids), but mainly secondary metabolites in moss extracts—including, sterols, terpenoids, polyphenols and others—and a high activity with respect to the studied test organisms.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.