A Mild and Regioselective Ring-Opening of Aziridines with Acid Anhydride Using TBD or PS-TBD as a Catalyst

Molecules

Satoru Matsukawa¹  Yasutaka Mouri² 

[1] Department of Science Education, Faculty of Education, Ibaraki University, Ibaraki 310-8512, Japan; E-Mail

关键词: organocatalyst;    basecatalyst;    polymercatalyst;    guanidine;    aziridine;    amino alcohols;   

DOI  :  10.3390/molecules201018482

来源: mdpi

【 摘 要 】

The ring-opening of N-tosylaziridines with various acid anhydrides catalyzed by 5 mol % of 1,5,7-triazabicyclo[4,4,0]dec-5-ene (TBD) afforded the corresponding β-amino esters in excellent yields under mild reaction conditions. Polymer-supported catalyst, PS-TBD also acts as a good catalyst for this reaction. PS-TBD was easily recovered and reused with minimal loss of activity.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.