TBD- or PS-TBD-Catalyzed One-Pot Synthesis of Cyanohydrin Carbonates and Cyanohydrin Acetates from Carbonyl Compounds

Molecules

Miki Yoshioka¹  Satoru Matsukawa¹  Junya Kimura¹ 

[1] Department of Science Education, Faculty of Education, Ibaraki University, Ibaraki 310-8512, Japan;

关键词: organocatalyst;    basecatalyst;    guanidine;    cyanation;    cyanoester;   

DOI  :  10.3390/molecules21081030

来源: DOAJ

【 摘 要 】

Cyanation reactions of carbonyl compounds with methyl cyanoformate or acetyl cyanide catalyzed by 5 mol % of 1,5,7-triazabicyclo[4,4,0]dec-5-ene (TBD) were examined. Using methyl cyanoformate, the corresponding cyanohydrin carbonates were readily obtained in high yield for aromatic and aliphatic aldehydes and ketones. Similar results were obtained when acetyl cyanide was used as the cyanide source. The polymer-supported catalyst, PS-TBD, also acted as a good catalyst for this reaction. PS-TBD was easily recovered and reused with minimal activity loss.

【 授权许可】

Unknown