MicroRNA-302b Enhances the Sensitivity of Hepatocellular Carcinoma Cell Lines to 5-FU via Targeting Mcl-1 and DPYD

International Journal of Molecular Sciences

Donghui Cai²  Kang He²  Su𠆞 Chang²  Dongdong Tong²  Chen Huang¹ 

[1] Department of Genetics and Molecular Biology, Xi’an Jiaotong University College of Medicine, Xi’an 710061, China;

关键词: miR-302b;    5-Fluorouracil (5-FU);    sensitivity;    hepatocellular carcinoma cell lines;   

DOI  :  10.3390/ijms161023668

来源: mdpi

【 摘 要 】

MiR-302b is a member of miR-302-367 cluster. The miR-302-367 cluster played important roles in maintaining pluripotency in human embryonic stem cells (hESCs) and has been proved to be capable of suppressing cell growth in several types of cancer cell lines including Hepatocellular Carcinoma (HCC) Cell lines. However, the role that miR-302b plays in the 5-Fluorouracil (5-FU) sensitivity of HCC has not been known. This study showed that miR-302b could enhance the sensitivity to 5-FU in HCC cell lines and verified its two putative targeted genes responsible for its 5-FU sensitivity.

【 授权许可】

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.