Molecules | |
Study of the Biotransformation of Tongmai Formula by Human Intestinal Flora and Its Intestinal Permeability across the Caco-2 Cell Monolayer | |
Shuai Wu2  Wei Xu2  Fu-Rong Wang2  Xiu-Wei Yang1  | |
[1] State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Peking University, No. 38, Xueyuan Road, Haidian District, Beijing 100191, China; | |
关键词: tongmai formula; isoflavone; HPLC; traditional Chinese medicine; human intestinal flora; biotransformation; human Caco-2 cells monolayer; | |
DOI : 10.3390/molecules201018704 | |
来源: mdpi | |
【 摘 要 】
Tongmai formula (TMF) is a well-known Chinese medicinal preparation that contains isoflavones as its major bioactive constituents. As traditional Chinese medicines (TCMs) are usually used by oral administration, their fate inside the intestinal lumen, including their biotransformation by human intestinal flora (HIF) and intestinal absorption deserves study. In this work TMF extract was incubated with human intestinal bacteria under anaerobic conditions and the changes in the twelve main constituents of TMF were then investigated. Their intestinal permeabilities,
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
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