Limonoids from the Seeds of Swietenia macrophylla and Their Anti-Inflammatory Activities

Molecules

Li-Chai Chen⁴  Hsiang-Ruei Liao²  Pei-Yu Chen⁵  Wen-Lung Kuo³  Tsung-Hsien Chang⁶  Ping-Jyun Sung¹  Zhi-Hong Wen⁴  Jih-Jung Chen⁷ 

[1] National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan; E-Mail:;Graduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan; E-Mail:;Chung-Jen Junior College of Nursing, Health Sciences and Management, Chiayi 60077, Taiwan; E-Mail:;Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan; E-Mails:;Department of Pharmacy, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 81342, Taiwan; E-Mail:;Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan; E-Mail:;Department of Pharmacy, Tajen University, Pingtung 90741, Taiwan

关键词: Swietenia macrophylla;    Meliaceae;    structure elucidation;    limonoid;    anti-inflammatory activity;   

DOI  :  10.3390/molecules201018551

来源: mdpi

【 摘 要 】

A new limonoid, swietemacrophin (1), was isolated from the seeds of Swietenia macrophylla, together with five known compounds 2–6. The structure of 1 was determined through extensive 1D/2D-NMR and mass-spectrometric analyses. Swietemacrophin (1), humilinolide F (2), 3,6-O,O-diacetylswietenolide (3), 3-O-tigloylswietenolide (4), and swietemahonin E (5) exhibited inhibition (IC₅₀ values ≤ 45.44 μM) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP). Compounds 1, 4, 5, and swietenine (6) showed potent inhibition with IC₅₀ values ≤ 36.32 μM, against lipopolysaccharide (LPS)-induced nitric oxide (NO) generation.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.