New Phragmalin-Type Limonoids from Chukrasia tabularis and Their α-Glucosidase Inhibitory Activity

Molecules

Jun-Lin Peng²  Jun Wang²  Fan-Dong Kong²  Zi-Qi Liu³  Pei Wang²  Cui-Juan Gai²  Bei Jiang³  Wen-Li Mei²  Hao-Fu Dai²  John Beutler¹ 

[1] Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaKey Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China;College of Pharmacy and Chemistry, Dali University, Dali 671000, China;

关键词: Chukrasia tabularis;    Meliaceae;    limonoid;    α-Glucosidase inhibition activity;   

DOI  :  10.3390/molecules21010058

来源: mdpi

【 摘 要 】

Phytochemical investigation on the stems of C. tabularis led to the isolation of five new phragmalin-type limonoids and six known ones. The structures of the new compounds 1–5, named chukbularisins A–E, were elucidated by spectroscopic techniques (IR, HRESIMS, 1D and 2D NMR) and comparisons with published data. All the compounds were evaluated for in vitro α-glucosidase inhibitory activity. Compounds 2, 3, 4, 5, and 8 exhibited inhibitory activity against α-glucosidase with IC₅₀ values of 0.06 ± 0.008, 0.04 ± 0.002, 0.52 ± 0.039, 1.09 ± 0.040, and 0.20 ± 0.057 mM, respectively (using acarbose as positive control, IC₅₀ 0.95 ± 0.092 mM).

【 授权许可】

CC BY   
© 2016 by the authors; licensee MDPI, Basel, Switzerland.