International Journal of Molecular Sciences | |
Folic Acid Inhibits Amyloid β-Peptide Production through Modulating DNA Methyltransferase Activity in N2a-APP Cells | |
Wen Li1  Mingyue Jiang1  Shijing Zhao1  Huan Liu1  Xumei Zhang1  John X. Wilson2  Guowei Huang1  | |
[1] Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin 300070, China; E-Mails:;Department of Exercise and Nutrition Sciences, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY 14214, USA; E-Mail: | |
关键词: Alzheimer’s disease; folic acid; DNA methyltransferases; amyloid β-peptide; | |
DOI : 10.3390/ijms161025002 | |
来源: mdpi | |
【 摘 要 】
Alzheimer’s disease (AD) is a common neurodegenerative disease resulting in progressive dementia, and is a principal cause of dementia among older adults. Folate acts through one-carbon metabolism to support the methylation of multiple substrates. We hypothesized that folic acid supplementation modulates DNA methyltransferase (DNMT) activity and may alter amyloid β-peptide (Aβ) production in AD. Mouse Neuro-2a cells expressing human APP695 were incubated with folic acid (2.8–40 μmol/L), and with or without zebularine (the DNMT inhibitor). DNMT activity, cell viability, Aβ and DNMTs expression were then examined. The results showed that folic acid stimulated
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
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