Dendrimer-Functionalized Laponite Nanodisks as a Platform for Anticancer Drug Delivery

Nanomaterials

Rania Mustafa²  Yu Luo²  Yilun Wu²  Rui Guo²  Xiangyang Shi²  Subramanian Tamil Selvan¹ 

[1] College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China;;College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China; E-Mails:

关键词: drug delivery system;    laponite;    PAMAM dendrimer;    anticancer efficacy;   

DOI  :  10.3390/nano5041716

来源: mdpi

【 摘 要 】

In this study, we synthesized dendrimer-functionalized laponite (LAP) nanodisks for loading and delivery of anticancer drug doxorubicin (DOX). Firstly, LAP was modified with silane coupling agents and succinic anhydride to render abundant carboxyl groups on the surface of LAP. Then, poly(amidoamine) (PAMAM) dendrimer of generation 2 (G2) were conjugated to form LM-G2 nanodisks. Anticancer drug DOX was then loaded on the LM-G2 with an impressively high drug loading efficiency of 98.4% and could be released in a pH-sensitive and sustained manner. Moreover, cell viability assay results indicate that LM-G2/DOX complexes could more effectively inhibit the proliferation of KB cells (a human epithelial carcinoma cell line) than free DOX at the same drug concentration. Flow cytometry analysis and confocal laser scanning microscope demonstrated that LM-G2/DOX could be uptaken by KB cells more effectively than free DOX. Considering the exceptional high drug loading efficiency and the abundant dendrimer amine groups on the surface that can be further modified, the developed LM-G2 nanodisks may hold a great promise to be used as a novel platform for anticancer drug delivery.

【 授权许可】

CC BY   
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