Metagenomics: A New Way to Illustrate the Crosstalk between Infectious Diseases and Host Microbiome

International Journal of Molecular Sciences

Yinfeng Zhang¹  Cheuk-Yin Lun¹  Stephen Kwok-Wing Tsui¹ 

[1] School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China;

关键词: microbiome;    metagenomics;    next generation sequencing;    infectious disease;    HIV;    HBV;    influenza;    tuberculosis;   

DOI  :  10.3390/ijms161125957

来源: mdpi

【 摘 要 】

Microbes have co-evolved with human beings for millions of years. They play a very important role in maintaining the health of the host. With the advancement in next generation sequencing technology, the microbiome profiling in the host can be obtained under different circumstances. This review focuses on the current knowledge of the alteration of complex microbial communities upon the infection of different pathogens, such as human immunodeficiency virus, hepatitis B virus, influenza virus, and Mycobacterium tuberculosis, at different body sites. It is believed that the increased understanding of the correlation between infectious disease and the alteration of the microbiome can contribute to better management of disease progression in the future. However, future studies may need to be more integrative so as to establish the exact causality of diseases by analyzing the correlation between microorganisms within the human host and the pathogenesis of infectious diseases.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.